Three-dimensional solution for deep and tunneling wounds

Foot Abscess Treated With Miro3D Wound Matrix

Clinical Overview and History

50 year old female with a history of diabetes who presented in the emergency department with cellulitis and ulceration sub right first metatarsophalangeal joint (MPJ). The patient had been treating the ulceration with Betadine® and using a controlled ankle motion (CAM) walker boot for 2 weeks prior to the visit.

Health history includes diabetes mellitus, neuropathy, high blood pressure, high cholesterol, hypothyroidism, and a deformity of the right foot.

Initial Findings

Labs indicated WBC = 9.5, anemia, elevated glucose, Cr = 0.89. Radiographic imaging showed no evidence of osteomyelitis. MRI results showed subcutaneous fluid thought to be an abscess at plantar 1st MPJ and mild edema noted within lateral sesamoid.

The ulceration contained odorous, serosanguinous drainage and undermining with necrotic tissue. Cellulitis was present along the periphery of the ulceration.

Treatment

Four days later, the patient was brought into the operating room for incision and drainage of the right foot abscess with right lateral sesamoidectomy. Silver Alginate was applied along with a dry dressing. A wound VAC applied and utilized during the five day hospital stay.

The patient was prescribed IV antibiotics upon discharge from the hospital but the wound VAC was discontinued due to insurance coverage challenges.

Approximately two and half weeks from the original incision and drainage surgery, the patient returned for outpatient surgical debridement using a VERSAJET Hydrosurgery System. The wound measured 2cm x 2.2cm x 2cm and contained moderate serosanguineous drainage (Figure 1). Following debridement, a Miro3D (3cm x 3cm x 2cm) wound matrix was applied followed by a nonadherent dressing, Steri-Strips, Silver Aginate and dry dressings (Figure 2).

Post 35 days from the Miro3D placement, the diameter of the wound measured 1.5cm x 1.5cm with 0.5cm in depth (Figure 3). No odorous drainage was present. Fibrous tissue and slough were noted. The wound was debrided using a currette and Miro3D (3cm x 3cm x 2cm) was placed for the second time (Figure 4). Adaptic™, Steri-Strips™, Silver Alginate, and dry dressings were used to secure Miro3D in place.

At follow up, three days following the second placement of Miro3D, the measurements of the wound were 1.4cm x 1.1cm x 0.3cm (Figure 5). No debridement was performed. Adaptic™, Silver Alginate, and dry dressings were utilized.

One week later, the wound measurements on the right foot were 1.2cm x 1.1cm x 0.3cm. A Total Contact Cast (TCC) was applied with collagen, Hydrofera Blue(R) dressing, and an ABD with Kerlix gauze dry dressing. The patient was prescribed oral antibiotics long term for suppression.

The patient continued to attend weekly follow up visits at the wound care center. Each visit the wound was debrided, and standard dressings were applied with the TCC. The following are the wound measurements at each follow up time-points from the second application of Miro3D:

• Post 31 days the wound measured: 1cm x 0.8cm x 0.1cm (Figure 6).
• Post 38 days the wound measured: 0.8cm x 0.6cm x 0.1cm (Figure 7).

Conclusion and Post Procedure

After one final week in the TCC, the wound was fully healed post 52 days following the second application of Miro3D, 87 days from the initial application of Miro3D (Figure 8).

Summary

The 2cm thickness of Miro3D allowed for full wall apposition and conformity to this deep wound bed. Along with proper off-loading, Miro3D provided a protective environment enabling the wound to achieve full healing within 12 weeks after only two applications of Miro3D.

Physician Information

Raymond John Abdo, DPM, Mercy Hospital South, St. Louis, Missouri
Dr. Raymond Abdo DPM is a foot and ankle surgeon in Saint Louis, MO specializing in Foot & Ankle Surgery and Podiatry (Foot & Ankle Medicine). Dr. Abdo is also in private practice at locations in St. Louis and Eureka, MO. He graduated from Des Moines University College of Podiatric Medicine and Surgery in 2002 and has 19 years of experience. Raymond Abdo DPM is affiliated with Mercy Hospital – St. Louis and Mercy (Arkansas, Kansas, Missouri, and Oklahoma).

Abdominal Surgical Dehiscence Post Panniculectomy With Miro3D Applied to Wound

Clinical Overview and History

Female patient who underwent a panniculectomy surgery in May 2022.

Initial Findings

Approximately two and half months later, the patient presented with an abdominal surgical wound dehiscence. The wound measured 8cm x 2cm x 0.5cm in depth with 2cm of medial tunneling.

A wound VAC was applied. The wound VAC dressing was disrupted and not repositioned which resulted in superficial skin breakdown on the superior part of the wound opening. The VAC was removed by the patient before the two week follow-up visit.

Treatment

Two weeks later, and because of the discontinued use of the wound VAC by the patient, the main wound measured 9cm x 2.7cm x 2cm in depth with 2.5cm of medial tunneling (Figure 1). Miro3D (5cm x 5cm x 2cm size) was applied to the tunneling space and the main body wound (Figure 2). The Miro3D was covered with Mepitel® dressing and secured with an ABD dressing. The patient was instructed to perform daily outer dressing changes and Vashe® wound solution rinses to keep the wound clean. A wound VAC was not reapplied.

Seven days following the initial placement of Miro3D, the wound measured 7.5cm x 2.5cm x 0.5cm in depth with no tunneling (Figure 3). The Miro3D was resorbed into the wound bed. Daily wet to dry dressing changes were initiated.

Three days later, the patient returned for a second application (Figure 4). A 5cm x 5cm x 2cm Miro3D was reapplied to the wound.

Four days after the second placement of Miro3D, the wound measured 7.25cm x 1.25cm x 0.5cm deep and Miro3D was noted as fully resorbed within the wound bed (Figure 5). The wound was washed with a wound solution and covered with a dry dressing. The patient was instructed to perform daily Vashe washes with dry dressing changes. The patient returned for follow-up appointments every one to three weeks as transportation resources allowed.

By day 54, following the second placement of Miro3D, the wound measured 2cm x 1cm x 0.4cm (Figure 6).

77 days from the second placement of Miro3D, observations of the wound included a significant reduction in size and continued wound healing (Figure 7).
On day 98, the wound measured 0.4cm x 0.4cm x 0.2cm (Figure 8).

Conclusion and Post Procedure

Full wound healing was observed in January 2023, which was 127 days from the initial Miro3D application to the wound (Figure 9).

Summary

In this case, the ability to cut and shape Miro3D to conform to the wound bed for full wound wall apposition in both the tunneling space and main wound bed was beneficial. Miro3D demonstrated volume replacement by quickly eliminating the initial tunneling area as well as reducing the size of the wound with the protection of the collagen scaffold. Full healing was achieved 127 days following the placement of Miro3D.

Physician Information

Moses K. Shieh, DO, FACOS, Medical Director & Founder of Surgical Healing Arts Center in Fort Myers, FL
Specializes in Advanced Laparoscopic Bariatric Surgery and General Surgery. Surgical Director of Robotic Surgery at Gulf Coast Medical Center (part of the Lee Health System) in Fort Myers and currently serves as a member of the Medical Executive committee. Wound Director for Landmark Hospital in Naples.

Large Sebaceous Cyst Excised And Successfully Treated With Miro3D Wound Matrix

Clinical Overview and Initial Findings

Patient presented to the clinic for a scheduled pre-operative appointment prior to a planned hernia repair surgery.

Upon the perioperative visit, the patient was found to have an infected, draining sebaceous cyst in the upper scapular region. Due to the discovery, the hernia repair was postponed. The patient was started on oral antibiotic therapy for 14 days prior to excision of the cyst.

Treatment

The sebaceous cyst was excised leaving a wound size of 11cm x 7cm (Figure 1). Miro3D wound matrix (10cm x 5cm x 2cm) was placed onto the wound with WHITEFOAM™ and a wound VAC 125mmHg.

Five days post excision and after placement of Miro3D and a wound VAC, small visual residual amounts of Miro3D was observed within the wound bed (Figure 2). The wound bed was left undisturbed and not debrided at this time to allow any residual Miro3D to continue to incorporate. The wound was dressed with a non adherent and secured in place with a standard secondary dressing.

Ten days later, post 15 days from the initial Miro3D application, the wound measured 9cm x 5cm (Figure 3). Standard care of debridement and dressings were performed.

Post 22 days from excision and placement of Miro3D, healthy granulation tissue was observed within the wound bed (Figure 4).

Due to prolific granulation tissue (Figure 5), silver nitrate was applied post 36 days from excision and the placement of Miro3D (Figure 6). The physician was pleased with the continued healing process and indicated he would rather apply an antidote to prolific granulation overgrowth vs. be challenged with minimal granulation tissue growth and wound stalling.

By 43 days, the wound measured 7cm x 3cm (Figure 7). Silver nitrate was applied a second time due to hypergranulation tissue.

The patient continued with dry dressing changes as needed and followed up in the clinic weekly. The wound continued to decrease in size with the following measurements and timepoints from excision and placement of Miro3D:

• Post 56 days wound measured: 5cm x 2.5cm (Figure 8)
• Post 63 days wound measured: 3.5cm x 1.5cm (Figure 9)
• Post 83 days wound measured: 1.2cm x 0.8cm (Figure 10)

Conclusion and Post Procedure

Full wound healing was achieved on day 97 (Figure 11).

Summary

Due to the highly porous structure of Miro3D, it is able to conform well to the intended space and quickly integrate into the wound bed providing a protective environment for wound management. This quick integration was demonstrated post 5 days from placement, allowing the wound to fully heal within 97 days after only one application of Miro3D. Subsequently, the patient was able to undergo a successful hernia repair surgery on day 97.

Physician Information

Rodney Miller, MD, General Surgery, Crossroads Providers 
Board-certified general surgeon with specialized training in robotic surgery. Dr. Miller obtained his medical degree and completed his general surgery residency at East Tennessee State University and has over 25 years of experience. Dr. Miller completed his fellowship in Laparoscopic Colectomy Hands-On from Washington University, a fellowship in Healogics Advanced Wound Care and Hyperbaric Oxygen Therapy in Destin Florida, and an Advanced Laparoscopic Nissen Education Curriculum from the University of Nebraska Medical Center School of Medicine.